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The arthritis drug Humira has been a blockbuster seller for more than two decades. Now some copycats could end Humira's reign.

The U.S. Transportation Department said Thursday it has received more than 100 complaints from owners of the 2010 Toyota Prius and has opened an investigation into possible brake problems with the model. That's more bad news for Toyota, which has recalled more than 5 million vehicles of various models to repair problems with sudden acceleration.

President Obama challenged leaders gathered at the U.N. General Assembly on Wednesday to join the U.S. in solving the world's problems rather than waiting for America to do it on its own. Obama used his first address to the U.N. General Assembly to calls for a "new era of engagement."

G-20 leaders will likely leave Pittsburgh with an agreement to have banks build up their capital reserves while cutting back on bonuses and other forms of compensation. The new capital rules will be phased in and banks would have until the end of 2012 to meet the new requirements.

Iranian envoys meet Thursday in Geneva with representatives from Europe, Russia, China and the U.S. for talks that will focus on Tehran's suspect nuclear program. The meeting comes as Iran's foreign minister visited Washington on Wednesday on a rare visit.

U.N. and Afghan officials confirmed reports of fraud in the Aug. 20 presidential elections and ordered a partial recount. The latest returns from the Afghan Election Commission show incumbent President Hamid Karzai now has enough votes to avoid a run-off with his nearest challenger.

The U.S. Senate Finance Committee rejected a provision to include a government-run public insurance option as part of the effort to overhaul the health care system. The vote was 15-to-8 against the measure.

Representatives from the U.S. and five other world powers outlined their concerns about Iran's nuclear program at a meeting in Switzerland with an Iranian delegation. U.S. officials held the highest-level direct talks with the Iranians in years.

In Austin, Texas, a small private plane crashed into a federal office building that housed Internal Revenue Service workers. Initial reports indicate the pilot hated the IRS and may have crashed the plane intentionally.

President Obama said Tuesday Democrats and Republicans should be able to come together and pass a jobs bill. The comments came at a meeting with congressional leaders from both parties.