Authorities say two people died and a third was injured when an 18-wheeler in which they were riding ran off Interstate 12 near Lacombe, struck a tree and caught fire.
State police tell The Times-Picayune the injured person was taken to the Interim LSU Public Hospital in New Orleans with serious injuries.
Identities of the victims were not immediately released.
The tractor-trailer rig ran off the highway's eastbound lanes near the Lacombe exit in St. Tammany Parish.